Journal of Oral Disease Markers - VOLUME 2 2018
Original Article
Assessing for potential correlation between platelet count and varying grades of oral squamous cell carcinoma
Madhuja Bhagali, Archana A. Gupta, Sangeeta Palaskar
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ABSTRACT

Introduction: The histopathological grade of oral squamous cell carcinoma (OSCC) is considered as a vital indicator for predicting the prognosis including the potential for local and distant metastasis. Similar to the histopathological grading, tumor-related angiogenesis is also an essential indicator of metastasis as it provides a pathway for the passage of tumor cells to distant sites. Studies have shown platelets to promote angiogenesis, which, in turn, could increase the risk of metastasis. Based on the above premise, the present study investigates the association between platelet count and the various grades of OSCC. The hypothesis of the study is that platelet counts increase with increasing grades of tumor, thus could be a potential prognostic marker for OSCC.

Aim: The study aims to assess any potential correlation between platelet count and varying grades of OSCC.

Materials and Methods: Clinical data and hematological data were retrieved from 140 histopathologically diagnosed cases of OSCC. Data were tabulated and statistically analyzed to correlate its association with tumor differentiation.

Results: Comparisons were made based on gender, tumor differentiation, and platelet counts. The correlation of platelet count with different grades of OSCC was statistically insignificant.

Conclusion: The lack of correlation between platelet count and OSCC grade could be due to the uneven distribution of the cases, especially due to the underrepresentation of poorly differentiated OSCC. Thus, further large-scale multicenter prospective studies with equal distribution of OSCC grades are needed to determine the interrelationship between platelets and tumor grade.

How to cite this article: Bhagali N, Gupta AA, Palaskar S. Assessing for potential correlation between platelet count and varying grades of oral squamous cell carcinoma. J Oral Dis Markers 2018;19-22.

Keywords: Grading, Metastasis, Oral squamous cell carcinoma, Platelets, Prognosis

Received: 09 August 2018;

Accepted: 23 October 2018

 
LETTER TO THE EDITOR
Intra-oral periapical radiograph can aid in the diagnosis of oroantral fistula
Vagish Kumar L S
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ABSTRACT

Dear Sir,
A 60-year-old patient visited the dental clinic with a chief complaint of painful swelling on the right side of the middle third of face for the past 1 week. The patient gives a history of extraction of a maxillary molar 10 days back, following which he developed the painful swelling. There was no history of regurgitation of fluids from the oral cavity to the nasal cavity.

How to cite this article: Shanbhag VKL. Intra-oral periapical radiograph can aid in the diagnosis of oroantral fistula. J Oral Dis Markers 2018;17-18.

Received: 26 September 2018,

Accepted: 30 September 2018

 
Review Article
Dynamics of myoepithelial cells in salivary gland lesions: An update
Aanchal Adwani, Supriya Kheur, Archana A. Gupta, Priyanka Bhagat
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ABSTRACT

Myoepithelial cells (MECs) are one of the non-secretory components of salivary gland acini. They are specialized cells capable of contraction aiding in the expulsion of saliva. They lie on the basement membrane of salivary gland acini and intercalated ducts. Tamarin described their resemblance as “like an octopus sitting on a rock.” Despite their smooth muscle-like properties, the presence of cytokeratin filaments confirms the epithelial origin of MECs. These cells are difficult to identify in routine hematoxylin and eosin staining. Several histochemical and immunohistochemical markers have been advocated for its identification. Neoplastic MECs are vital in the morphogenesis of various salivary gland tumors and are responsible for the histologic diversity of these tumors. This review describes the dynamics of the MEC, its pathophysiology, morphologic, and cytologic changes in various salivary gland tumors.

Keywords: Basket cells, myoepithelial cells, non-ductal cells, salivary gland tumors

How to cite this article: Adwani A, Kheur S, Gupta AA, Bhagat P. Dynamics of myoepithelial cells in salivary gland lesions: An update. J Oral Dis Markers 2018;13-16.

Received: 06 September 2018;

Accepted: 15 September 2018

 
Original Article
Evaluation of relationship between duration of lactation and tooth loss in postmenopausal women in a South Indian population - A cross-sectional survey
Shanmugapriya Ramamurthy, Rathinasamy Kadiresan, Arunmozhi Ulaganathan, Sabitha Sudarsan, Sujatha Govindarajan, Anugraha Thankam
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ABSTRACT

Background: Osteoporosis and periodontitis are chronic diseases characterized by bone loss. Both these conditions consist of multifactorial etiology and risk factors. Changes in bone metabolism are often reported during lactation, yet their effect on dental health is relatively unexplored. Thus, it is essential to investigate the association between breastfeeding and oral health changes.

Aim: The objective of our study is to assess the relationship between the period of breastfeeding and the total number of teeth present in postmenopausal women in a South Indian population.

Settings and Design: The current study was a cross-sectional survey of 500 postmenopausal women with a mean age of 61.7 years. They were interviewed to collect details on the duration of lactation, other reproductive factors and examined for the total number of natural teeth present.

Materials and Methods: The collected data were classified into three groups with respect to the duration of breastfeeding as Group I - 24–36 months, Group II - 37–60 months, and Group III - >60 months. Student’s t-test was done to compare the means. One-way analysis of variance was done to analyze the association followed by Tukey post hoc test.

Results: The group having the longest lactation period Group III (>60 months) had the lowest number of natural teeth (13.04 ± 6.026). The total number of the teeth was significantly greater in Group I compared to Group II (mean =7.065) and Group III (mean =8.731). Group II and Group III did not show a significant difference (mean =3.409).

Conclusions: Women with a longer duration of breastfeeding presented with significantly less number of teeth. The changes in bone metabolism brought about by longer periods of breastfeeding might increase the susceptibility of those patients to periodontal bone loss and subsequently lead to tooth loss in postmenopausal women.

Keywords: Breastfeeding, lactation, osteoporosis, periodontal pocket, postmenopause, tooth loss.

How to cite this article: Ramamurthy S, Kadiresan R, Ulaganathan A, Sudarsan S, Govindarajan S, Thankam A. Evaluation of relationship between duration of lactation and tooth loss in postmenopausal women in a South Indian population - A cross-sectional survey. J Oral Dis Markers 2018;8-12.

Received: 18 February 2018;

Accepted: 02 September 2018

 
Case Report
Psychological/psychosocial stress and periodontal diseases: An intricate web
Ghaziya Ghansh, R. Shanmuga Priya, Sabitha Sudarsan, Manikandan Krishnan
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ABSTRACT

Currently, several clinical studies have documented a positive relationship between psychological/psychosocial stress and chronic periodontal disease. Stress in the least form has known to impact periodontal health through changes in the individual behavior and loaded with the potential to affect the pathogenesis of periodontal disease. Although a direct association remains to be proven, recent studies indicate that psychological/psychosocial stress definitely possesses as a potential risk indicator for periodontal disease and, hence, should be addressed as and when the situation demands. This article seeks to highlight the subtle link between the above-stated risk factors and periodontal disease by quoting an instance of compromised oral maintenance leading to premature tooth loss.

Keywords: Fear, oral health, periodontium, psychotic disorder, stress

How to cite this article: Ghansh G, Priya RS, Sudarsan S, Krishnan M. Psychological/psychosocial stress and periodontal diseases: An intricate web. J Oral Dis Markers 2018;5-7.

Received: 08 March 2018;

Accepted: 19 July 2018

 
Original Article
Incidence of the oral protozoa - Entamoeba gingivalis in a hospital-based population in South India - A preliminary study
Shanmugapriya Ramamurthy, Sabitha Sudarsana, Shyam Sivasamy, Arunmozhi Ulaganathan, Kadhiresan Rathinasamy, Sujatha Govindarajan
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ABSTRACT

Background: Protozoa are single-cell animal organisms that can divide within a host organism. The oral protozoan Entamoeba gingivalis has held a rather chequered position in the history of research. Keyes in 1983 noted that this organism together with the cocci which colonize the surface of the actinomyces filaments was invariably found in close proximity to plaque, especially in patients with poor oral hygiene.

Aim: The aim of this study is to evaluate the incidence of the oral protozoan E. gingivalis in a hospital-based population (attending the outpatient clinic) in a dental institution in South India.

Materials and Methods: The objective of this clinical study was to investigate the prevalence of E. gingivalis in periodontal diseases and to compare its occurrence among gingivitis and periodontitis group and with healthy controls. It is a cross-sectional comparative clinico-microbiological study. Criteria-based sampling was undertaken among patients visiting a dental college in South India. The plaque sample was collected with a sterile curette (Gracey Curette) from the gingival crevice/periodontal pocket and immediately subjected to light microscopic examination by an original wet-smear technique for the presence of E. gingivalis.

Results: The results revealed that while 88% of gingivitis patients showed the presence of E. gingivalis, 76% of periodontitis patients and only 4% of healthy subjects showed its presence.

Conclusions: The results of this preliminary study showed an increased presence of E. gingivalis in plaque samples of both gingivitis and periodontitis patients when compared to healthy subjects. The incidence of the parasite, as well as the intensity of the gingival infection, is correlated.

Keywords: Commensal, Entamoeba gingivalis, gingivitis, microbiome, periodontitis, protozoa

How to cite this article: Ramamurthy S, Sudarsana S, Sivasamy S, Ulaganathan A, Rathinasamy K, Govindarajan S. Incidence of the oral protozoa - Entamoeba gingivalis in a hospital-based population in South India - A preliminary study. J Oral Dis Markers 2018;1-4.

Received: 08 March 2018;

Accepted: 06 July 2018

 
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